Cardiomyocyte calcium dynamics
Autor
Tipus de document
Treball d'assignatura
Data
2017
rights
Accés obert
Editorial
Universitat Politècnica de Catalunya
Any acadèmic
2016/2017
Assignatures
Titulacions
UPCommons
Resum
Contraction of the cardiac muscles starts with an action potential acting as a signal, which depolarizes
myocytes, making them to contract. Ca 2+ is key in both processes, signaling and contraction; in this work
we are going to focus in the role its concentration plays in contraction of cardiomyocytes, and therefore
beating of the heart. A cardiac cell can be modelled as an array of Calcium Release Units (CaRUs), each of
which present five different compartments and calcium concentration; the response of this concentrations to
the external action potential determines the cardiac contraction.

Professorat participant
- Gutiérrez de la Cal, Xabier
- Rojo González, Javier