Cardiomyocyte calcium dynamics

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Autor

Gutiérrez de la Cal, Xabier

Rojo González, Javier

Tipus de document

Treball d'assignatura

Data

2017

rights

Accés obertOpen Access

Editorial

Universitat Politècnica de Catalunya

Any acadèmic

2016/2017



Resum

Contraction of the cardiac muscles starts with an action potential acting as a signal, which depolarizes myocytes, making them to contract. Ca 2+ is key in both processes, signaling and contraction; in this work we are going to focus in the role its concentration plays in contraction of cardiomyocytes, and therefore beating of the heart. A cardiac cell can be modelled as an array of Calcium Release Units (CaRUs), each of which present five different compartments and calcium concentration; the response of this concentrations to the external action potential determines the cardiac contraction.
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